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  论文及专著

近年发表论文:
2014年
1. Zhixia Qiu, Ning Li, Ling Song, Yang Lu, Wenchao Gao, Fengjie Tian, Xin Wang, Qi Liu, Shuangxia Ren, Xijing Chen. Contributions of intestine and plasma to the presystemic bioconversion of vicagrel, an acetate of clopidogrel. Pharmaceutical Research. 2014, 31: 238-251. [Download]

2. Ning Li, Zhixia Qiu, Xuliang Wang, Hui Ji, Tingting Li, Yihua Zhang, Yang Lu, Xijing Chen. Pharmacokinetics in Sprague-Dawley rats and beagle dogs and in vitro metabolism of ZJM-289, a novel nitric dioxide donor. Xenobiotica. 2014, 44: 59-69. [Download]

3. Shuoye Yang, Amer Talbi, Xin Wang, Hanlin Song, Xijing Chen. Pharmacokinetics study of calf thymus DNA in rats and beagle dogs with 3H-labeling and tracing method. Journal of Pharmaceutical and Biomedical Analysis. 2014, 88:60-65. [Download]

4. Di Zhao, Yongjie Zhang, Yue Wang, Chunxiang Xu, Can Dong, Cuiyun Li, Shuangxia Ren, Wei Zhang, Yang Lu, Yue Dai, Xijing Chen. Pharmacokinetics study of hemin in rats by applying 58Fe-extrinsically labeling techniques in combination with ICP-MS method. Journal of Pharmaceutical and Biomedical Analysis. 2014, 88: 331-336. [Download]

5. Yang Lu, Jing Jing, Weichao Ren, Jing Zhu, Zhixia Qiu, Ning Li, Xiaonan Li, Di Zhao, Harendra S. Parekh, Xijing Chen. Biliary excretion of glycyrrhetinic acid: glucuronide-conjugate determination following a pharmacokinetic study of rat bile. Phytotherapy Research. 2014. [Download]

6. Shuhua Deng, Chunfeng Wang, Wei Zhang, Wenchao Gao, Ali Fan, Qiuyang Zhang, Yongjie Zhang, Qingwang Liu, Ning Li, Qi Liu, Jie Zhao, Cuiyun Li, Xingyuan Wen, Di Zhao, Xijing Chen. Effect of triacontanol on the pharmacokinetics of docetaxel in rats associated with induction of cytochrome P450 3A1/2. Xenobiotica. 2014. [Download]

7. Sufeng Zhou, Ning Li, Xin Wang, Cuiyun Li, Fengjie Tian, Shuangxia Ren, Yuehua Zhang, Yuanping He, Zhixia Qiu, Di Zhao, Xijing Chen. In vitro cytotoxicity, pharmacokinetics and tissue distribution in rats of MXN-004, a novel conjugate of polyethylene glycol and SN38. Xenobiotica. 2014, 44:562-569. [Download]

8. Xiaonan Li, Ning Li, Chunfeng Wang, Shuhua Deng, Xiaolin Sun, Wei Zhang, Wenchao Gao, Di Zhao, Yang Lu, Xijing Chen. Development and validation of a simple and reliable LC-MS/MS method for the determination of acetazolamide, an effective carbonic anhydrase inhibitor, in plasma and its application to a pharmacokinetic study. Drug Research. 2014. [Download]

9. Cuiyun Li, Shuangxia Ren, Yu Dai, Fengjie Tian, Xin Wang, Sufeng Zhou, Shuhua Deng, Qi Liu, Jie Zhao, Xijing Chen. Efficacy, pharmacokinetics, and biodistribution of thermosensitive chitosan/beta-glycerophosphate hydrogel loaded with docetaxel. AAPS PharmSciTech. 2014, 15: 417-424 [Download]

10. Jie Zhao, Yanli Wen, Wei Zhang, Di Zhao, Ali Fan, Yongjie Zhang, Shuhua Deng, Xin Wang, Qingwang Liu, Yang Lu, Zhimei Wang, Shaohua Gou, Xijing Chen. Investigation on pharmacokinetics, tissue distribution and excretion of a novel platinum anticancer agent in rats by inductively coupled plasma mass spectrometry (ICP-MS). Xenobiotica. 2014. [Download]

11. Bing Yang, Ning Li, Yang Lu, Zhixia Qiu, Di Zhao, Pengfei Song, Xijing Chen. Pharmacokinetics of thiamphenicol glycinate and its active metabolite by single and multiple intravenous infusions in healthy Chinese volunteers. Xenobiotica. 2014. [Download]

12. Shuangxia Ren, Cuiyun Li, Yu Dai, Ning Li, Xin Wang, Fengjie Tian, Sufeng Zhou, Zhixia Qiu, Yang Lu, Di Zhao, Xijing Chen, Dingding Chen. Comparison of pharmacokinetics, tissue distribution and pharmacodynamics of liposomal and free doxorubicin in tumor-bearing mice following intratumoral injection. Journal of Pharmacy and Pharmacology. 2014. [Download]

13. Fengjie Tian, Cuiyun Li, Xin Wang, Shuangxia Ren, Ning Li, Qi Liu, Sufeng Zhou, Yang Lu, Di Zhao, Xijing Chen. Comparative study on pharmacokinetics of a series of anticholinergics, atropine, anisodamine, anisodine, scopolamine and tiotropium in rats. European Journal of Drug Metabolism and Pharmacokinetics. 2014. [Download]

14. Amer Talbi, Di Zhao, Qingwang Liu, Junxiu Li, Ali Fan, Wei Yang, Xing Han, Xijing Chen. Pharmacokinetics, tissue distribution, excretion and plasma protein binding studies of wogonin in rats. Molecules. 2014, 19: 5538-5549 [Download]

15. Jiake He, Yang Yu, Bhagwat Prasad, Xijing Chen, Jashvant D. Unadkat. Mechanism of an unusual, but clinically significant, digoxin-bupropion drug interaction. Biopharmaceutics & Drug Disposition. 2014, 35:253-263. [Download]

16. Chunfeng Wang, Shuhua Deng, Wenchao Gao, Wei Zhang, Wei Yang, Xiaojie Zhu, Yang Lu, Xijing Chen. Investigation on pharmacokinetics, tissue distribution and excretion of 1-triacontanol in rats by gas chromatography-tandem mass spectrometry (GC-MS/MS). Xenobiotica. 2014. [Download]

17. Jiake He, Yang Yu, Bhagwat Prasad, Jeanne M Link, Robert S Miyaoka, Xijing Chen, Jashvant D Unadkat. PET imaging of Oatp-mediated Hepatobiliary Transport of [11C] Rosuvastatin in the Rat. Molecular Pharmaceutics. 2014, 11:2745-2754. [Download]

18. Xiaonan Li, Xiaolin Sun, Jiayin Chen, Yang Lu, Yongjie Zhang, Chunfeng Wang, Junxiu Li, Qing Zhang, Di Zhao, Xijing Chen. Investigation of the role of organic cation transporter 2 (OCT2) in the renal transport of guanfacine, a selective α2A- adrenoreceptor agonist. Xenobiotica. 2014. [Download]

19. Shuoye Yang, Zhixia Qiu, Qiuyang Zhang, Jiayin Chen, Xijing Chen. Inhibitory effects of calf thymus DNA on metabolism activity of CYP450 enzyme in human liver microsomes. Drug Metabolism and Pharmacokinetics. 2014. [Download]

20. Qiuyang Zhang, Wei Yang, Hanlin Song, Hui Wu, Yang Lu, Jiake He, Di Zhao, Xijing Chen. Tissue distribution and ontogeny of multidrug resistance protein 2, a phosphatidylcholine translocator, in rats. European Journal of Drug Metabolism and Pharmacokinetics. 2014. [Download]

21. Chunfeng Wang, Ali Fan, Xiaojie Zhu, Yang Lu, Shuhua Deng, Wenchao Gao, Wei Zhang, Qi Liu, Xijing Chen. Trace quantification of 1-triacontanol in beagle plasma by GC-MS/MS and its application to a pharmacokinetic study. Biomedical Chromatography 2014. [Download]


2013年
1. Zhixia Qiu, Ning Li, Xin Wang, Fengjie Tian, Qi Liu, Ling Song, Zhen Fan, Yang Lu, Xijing Chen. Pharmacokinetics of vicagrel, a promising analogue of clopidogrel, in rats and beagle dogs. Journal of Pharmaceutical Sciences. 2013, 102: 741-749 [Download]

2. Yongjie Zhang, Di Zhao, Jie Xu, Chunxiang Xu, Can Dong, Qingwang Liu, Shuhua Deng, Jie Zhao, Wei Zhang and Xijing Chen. Effects of dietary factors on the pharmacokinetics of 58Fe labeled hemin after oral administration in normal rats and the iron deficiency rats. Biological Trace Element Research. 2013, 102(2):741-9 [Download]

3. Xin Wang, Ling Song, Ning Li, Zhixia Qiu, Sufeng Zhou, Cuiyun Li, Jie Zhao, Hanlin Song, Xijing Chen. Pharmacokinetics and biodistribution study of paclitaxel liposome in Sprague-Dawley rats and beagle dogs by liquid chromatography-tandem mass spectrometry. Drug Research. 2013, 63:603-606. [Download]

4. Xiaonan Li, Ning Li, Xiaolin Sun, Wei Yang, Yu Dai, Jie Xu, Wei Zhang, Chunfeng Wang, Suilou Wang, Xijing Chen. Development and validation of a simple, sensitive and accurate LC-MS/MS method for the determination of guanfacine, a selective α2A-adrenergic receptor agonist, in plasma and its application to a pharmacokinetic study. Biomedical Chromatography. 2013, 27: 1708-1713. [Download]


2012年
1. Di Zhao, Yongjie Zhang, Chunxiang Xu, Can Dong, Hui Lin, Lingli Zhang, Cuiyun Li, Shuangxia Ren, Xin Wang, Shuoye Yang, Deen Han and Xijing Chen. Pharmacokinetics, tissue distribution, and plasma protein binding study of platinum originating from dicycloplatin, a novel antitumor supramolecule, in rats and dogs by ICP-MS. Biological Trace Element Research. 2012, 148 (2): 203-208 [Download]

2. Shuoye Yang, Qiuyang Zhang, Jiayin Chen, Deen Han, Di Zhao and Xijing Chen. Pharmacokinetics and disposition study of calf thymus DNA in rats by applying 3H-labeling method. Journal of Pharmaceutical and Biomedical Analysis. 2012, 64-65: 35-39 [Download]

3. Lingli Zhang, Ning Li, Yisheng Lai, Yihua Zhang, Xijing Chen, Li Chen, Hui Ji and Cuiyun Li . Pharmacokinetic, distribution, metabolism, and excretion of (Z)-2-amino-1,5-dihydro-1-methyl-5-[4-(mesyl)benzylidene]-4H-imidazol-4-one mesilate (ZLJ-601) in Sprague-Dawley rats. Pharmacology. 2012, 89(3-4):192-200 [Download]

4. Shuoye Yang, Jiayin Chen, Di Zhao, Deen Han and Xijing Chen. Comparative study on preparative methods of DC-Chol/DOPE liposomes and formulation optimization by determining encapsulation efficiency. International Journal of Pharmaceutics. 2012, 434(1-2): 155-160 [Download]

5. Jianheng Zheng, Yi Zheng, Jiayin Chen, Fang Fang, Jiake He, Ning Li, Yue Tang, Jiabi Zhu, and Xijing Chen. The pulmonary absorption enhancing effect of recombinant human insulin by pulmonary surfactant and phospholipid hexadecanol tyloxapol through Calu-3 monolayers. Pharmazie. 67(5):448-451 [Download]

6. Fang Fang, Yang Lu, Yue Liang, Jing Zhu, Jiake He, Jianheng Zheng, Ning Li, Yue Tang, Jiabi Zhu and Xijing Chen. Evaluation of insulin lispro and biosynthetic human insulin in pulmonary absorption: in vivo and in vitro studies. Pharmazie. 67(8):706-711 [Download]

7. Shuoye Yang, Yi Zheng, Jiayin Chen, Quiyang Zhang, Di Zhao, Deen Han and Xijing Chen. Comprehensive study of cationic liposomes composed of DC-Chol and cholesterol with different mole ratios for gene transfection. Colloids and Surfaces B: Biointerfaces. 2012, 101(1): 6-13 [Download]

8. Liqun Jiang, Yue Tang, Hongjiu Zhang, Xifeng Lu, Xijing Chen and Jiabi Zhu. Importance of powder residence time for the aerosol delivery performance of a commercial dry powder inhaler aerolizer. Journal of Aerosol Medicine and Pulmonary Drug Delivery. 2012, 25(5): 265-279 [Download]

9. Lifang Yin, Shijing Huang, Chunli Zhu, Shuhui Zhang, Qiang Zhang, Xijing Chen and Qingwang Liu. In vitro and in vivo studies on a novel solid dispersion of repaglinide using polyvinylpyrrolidone as the carrier. Drug Development and Industrial Pharmacy. 2012, 38(11): 1371-1380 [Download]

10. Deen Han, Yi Zheng, Xijing Chen, Jiake He, Di Zhao, Shuoye Yang, Chunfeng Zhang and Zhonglin Yang. Identification and characterization of human UDP-glucuronosyltransferases responsible for the in vitro glucuronidation of salvianolic acid A. Drug Metabolism and Pharmacokinetics. 2012, 27: 579-585 [Download]


2011年
1. Bing Yang, Yang Lu, Jianheng Zheng, Jing Zhu, Jiake He, Di Zhao, Pengfei Song and Xijing Chen. Pharmacokinetics of the prodrug thiamphenicol glycinate and its active parent compound thiamphenicol in beagle dogs following intravenous administration. Xenobiotica. 2011, 41(3): 226-31 [Download]

2. Jiake He, Zhixia Qiu, Ning Li, Yang Yu, Yang Lu, Deen Han, Tingting Li, Di Zhao, Wei Sun, Fang Fang, Jianheng Zheng, Hongwei Fan and Xijing Chen. Effects of SLCO1B1 polymorphisms on the pharmacokinetics and pharmacodynamics of repaglinide in healthy Chinese volunteers. European Journal of Clinical Pharmacology. 2011, 67(7): 701-707 [Download]

3. Tingting Li, Yi Zheng, Feifei Fu, Hui Ji, Xijing Chen, Ying Zhao, Di Zhao, Ning Li, Lingli Zhang. Assessment of UDP-glucuronosyltransferase catalyzed formation of picroside II glucuronide in microsomes of different species and recombinant UGTs. Xenobiotica. 2011, 47:530-537 [Download]

4. Tingting Li, Qiaoling Yu, Deen Han, Ying Zhao, Di Zhao, Hui Ji, Xijing Chen,Ning Li, Zhixia Qiu, Yi Zheng. Structure elucidation of metabolites of picroside II in rat bile by LC-ESI-IT-MS. Chromatographia. 2011, 73:1111–1120 [Download]

5. Di Zhao, Zidong Gao, Deen Han, Ning Li, Yongjie Zhang, Yang Lu, Tingting Li, and Xijing Chen. Influence of rifampicin on the pharmacokinetics of salvianolic acid B may involve inhibition of organic anion transporting polypeptide (Oatp)-mediated influx. Phytotherapy Research. [Download]

6. Ning Li, Xuliang Wang, Tingting Li, Hui Ji, Yihua Zhang, Zhixia Qiu, Di Zhao and Xijing Chen. Identification of circulatory and excretory metabolites of a novel nitric oxide-donor ZJM-289 in rat plasma, bile, urine, and feces by liquid chromatography-tandem mass spectrometry. Xenobiotica. 2011, 41(9):805-817 [Download]

7. Tingting Li, Ning Li, Qinglong Guo, Hui Ji, Di Zhao, Shan Xie, Xiaonan Li, Zhixia Qiu, Deen Han, Xijing Chen, Qidong You. Inhibitory effects of wogonin on catalytic activity of cytochrome P450 enzyme in human liver microsomes. European Journal of Drug Metabolism and Pharmacokinetics. [Download]

8. Di Zhao, Deen Han, Ning Li, Yang Lu, Tingting Li, Shuoye Yang, Jiake He, and Xijing Chen. Simultaneous determination of six phenolic constituents of Danshen injection in rat plasma by LC-ESI-MS and its application to a pharmacokinetic study. European Journal of Mass Spectrometry. 2011, 17(4):395-403 [Download]


2010年
1. Zhao Y, Zhai D, Chen X, Yu Q, He H, Sun Y, Gao Z, Wang L, Wang H, Han D, Ji H. Determination of nimodipine in human plasma by HPLC-ESI-MS and its application to a bioequivalence study. Journal of Chromatographic Science. 2010, 48: 81-85 [Download]

2. De-En Han, Yi Zheng, Ning Li, Di Zhao, Ge Zhang, Hefeng Yan, Lingli Zhang, Wei Sun, Ya-Ning Wu, Yang Lu and Xijing Chen. Determination of nateglinide in human plasma by LC-ESI-MS and its application to bioequivalence study. Chromatographia. 2010, 71: 299-304 [Download]

3. Lei Wu, Ge Zhang, Qin Lu, Qian Sun, Mulan Wang, Na Li, Zidong Gao, Ya Sun, Tingting Li, Deen Han, Xue Yu, Lei Wang, Wei Sun, Di Zhao, Yaning Wu, Yang Lu and Xijing Chen. Evaluation of salmon calcitonin (sCT) enteric-coated capsule for enhanced absorption and GI tolerability in rats. Drug Development and Industrial Pharmacy. 2010, 36(3): 362-370 [Download]

4. Jianheng Zheng, Ge Zhang, Yang Lu, Fang Fang, Jiake He, Ning Li, Amer Talbi, Ying Zhang, Yue Tang, Jiabi Zhu, Xijing Chen. Effect of pulmonary surfactant and phospholipid hexadecanol tyloxapol on rh-insulin absorption from intratracheally administered dry powders in diabetic rats. Chemical and Pharmaceutical Bulletin. 2010,58(12): 1612-1616 [Download]

5. Weichao Ren, Yang Lu, Jing Jing, Jing Zhu, Di Wan, Di Zhao, Jianheng Zheng, Fang Fang, Yan He, and Xijing Chen. Determination of glycyrrhizin in dog plasma by liquid chromatography-mass spectrometry and its application in pharmacokinetic studies. European Journal of Mass Spectrometry. 2010, 16(6): 673-678 [Download]

2009年
1. Ying Zhao, Desheng Zhai, Hui He, Junhua Liu, Tingting Li, Xijing Chen and Hui Ji. Matrine improves 17α-ethinyl estradiol-induced acute cholestasis in rats. Hepatology Research. 2009, 39(11): 1144–1149 [Download]

2. Ying Zhao, Desheng Zhai, Hui He, Junhua Liu, Tingting Li, Xijing Chen and Hui Ji. Effects of CYP3A5, MDR1 and CACNA1C polymorphisms on the oral disposition and response of nimodipine in a Chinese cohort. European Journal of Clinical Pharmacology. 2009, 65(6):579-84 [Download]

3. Deen Han, Zidong Gao, Di Zhao, Lei Wang, Na Li, Tingting Li, Lei Wu and Xijing Chen. Liquid chromagraphy mass spectrometry for the determination of salvianolic acid B, a natural compound from the herb Danshen in rat plasma and application to pharmacokinetic study. Biomedical Chromatography. 2009, 23:1073-1078 [Download]

4. Ting-Ting Li, Fang Fang, Xi-Jing Chen, Hui Ji.LC Method for Determination and pharmacokinetic study of 5,6,7,8,30,40-hexamethoxy-3sulfonyl flavone in rat plasma. Chromatographia. 2009, 70: 1755-1758 [Download]

5. Yang Lu, Jing Zhu, Xijing Chen, Ning Li, Feifei Fu, Jiake He, Guangji Wang, Lingli Zhang, Yi Zheng, Zhixia Qiu, Xue Yu, Deen Han and Lei Wu. Identification of human UDP-glucuronosyltransferase isoforms responsible for the glucuronidation of glycyrrhetinic acid. [Download]

6. Yong Zhang, Jiabi Zhu, Yue Tang, Xijing Chen and Yan Yang. The preparation and application of pulmonary surfactant nanoparticles as absorption enhancers in insulin dry powder delivery. Drug Development and Industrial Pharmacy. 2009, 35: 1059-1065 [Download]

7. Lai L, Liu Y, Hao H, Wang G, Chen X, Ren H. Determination of 20(S)-ginsenoside Rh1 and its aglycone 20(S)-protopanaxatriol in rat plasma by sensitive LC-APCI-MS method and its application to pharmacokinetic study. European Journal of Mass Spectrometry. 2009, 15: 57-65 [Download]

 
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